A Change in Hemoglobins Structure Can Disturb Hemoglobin Function Essa

A Change in haemoglobins organize Can Disturb Hemoglobin FunctionAbstractThe fact that a molecule?s structure determines its function tooshie be seen throughthe oxygen transporter protein, hemoglobin. Hemoglobin can take two forms, oxy fixand deoxy state, and each performs a distinct function for the hemoglobin. In a normalhemoglobin, the oxygen binds to a heme group during the oxy state and releases oxygenduring the deoxy state. However, when hemoglobin is mutated like in reaping hook jail cell anemia,in which the amino acid glumatic acid is substituted with valine in the sixth position ofbeta subunit the hemoglobin will not function correctly in the deoxy state. This will leadthe hemoglobin to take a reaping hook shape that will in conclusion cause sickle cell anemia.Imagine doing an internship in the emergency department of the hospital,suddenly, a five year old suspensor comes to the ER that is having hard m breathing. Theresults from the tests that were d adept on t he athlete show that he could not become like hisidol, Michel Jordan, in basketball because he has sickle cell anemia. During the talk withone of the doctors that you were working with, you discover that sickle cell anemia is ahereditary disease that occurs due to the deficiency of the red line cells. This is causedby a genic mutation in the hemoglobin, an oxygen carrier protein, in which one aminoacid is changed to another. This mutation in the structure of the hemoglobin disturbs theproteins? normal function and last leads to sickle cell anemia. Have you wonderedhow this small change in the structure of hemoglobin can cause sickle cell anemia, and3stop the athlete from playing basketball? Well, this is one of the main topics that w... ...6um%3D1%26hl%3Den.(3)blood hemoglobin tetramer. Encyclopedia Britannica. 2007. EncyclopdiaBritannica, Inc. . 27 Jul 2008.(4) Porphyrin. The Free Dictionary. procure 2008 . Farlex, Inc.. 27 Jul 2008.(5)DR.JAKUBOWSKI,CHAPTER5-BINDING.05/16/08 .27Jul2008html.6)Voet, Donald. Biochemsitry . 1990. buttocks Wiely ,7, 8) ?How Does Sickle Cell Cause Disease?. April 11, 2002 . harvard . 27 Jul 2008.12AcknowledgmentsI acknowledge Dr. Peck, Mike, Bless and my professors from the chemistry clusterDean, Tim, and Tobey for invariably being there for me whenever I needed their help tospark this project. A Change in Hemoglobins Structure Can Disturb Hemoglobin Function EssaA Change in Hemoglobins Structure Can Disturb Hemoglobin FunctionAbstractThe fact that a molecule?s structure determines its function can be seen throughthe oxygen transporter protein, hemoglobin. Hemoglobin can take two forms, oxy stateand deoxy state, and each performs a distinct function for the hemoglobin. In a normalhemoglobin, the oxygen binds to a heme group during the oxy state and releases oxygenduring the deoxy state. However, when hemoglobin is mutated like in sickle cell anemia,in which the amino acid glumatic acid is substituted with val ine in the sixth position ofbeta subunit the hemoglobin will not function correctly in the deoxy state. This will leadthe hemoglobin to take a sickle shape that will eventually cause sickle cell anemia.Imagine doing an internship in the emergency department of the hospital,suddenly, a five year old athlete comes to the ER that is having hard time breathing. Theresults from the tests that were done on the athlete show that he could not become like hisidol, Michel Jordan, in basketball because he has sickle cell anemia. During the talk withone of the doctors that you were working with, you discover that sickle cell anemia is ahereditary disease that occurs due to the deficiency of the red blood cells. This is causedby a genetic mutation in the hemoglobin, an oxygen carrier protein, in which one aminoacid is changed to another. This mutation in the structure of the hemoglobin disturbs theproteins? normal function and eventually leads to sickle cell anemia. Have you wonderedhow this sma ll change in the structure of hemoglobin can cause sickle cell anemia, and3stop the athlete from playing basketball? Well, this is one of the main topics that w... ...6um%3D1%26hl%3Den.(3)blood hemoglobin tetramer. Encyclopedia Britannica. 2007. EncyclopdiaBritannica, Inc. . 27 Jul 2008.(4) Porphyrin. The Free Dictionary. Copyright 2008 . Farlex, Inc.. 27 Jul 2008.(5)DR.JAKUBOWSKI,CHAPTER5-BINDING.05/16/08.27Jul2008html.6)Voet, Donald. Biochemsitry . 1990. John Wiely ,7, 8) ?How Does Sickle Cell Cause Disease?. April 11, 2002 . harvard . 27 Jul 2008.12AcknowledgmentsI acknowledge Dr. Peck, Mike, Bless and my professors from the chemistry clusterDean, Tim, and Tobey for always being there for me whenever I needed their help tospark this project.